PhD Studentship: Actuated microdevices for oral delivery of biologics
University of Birmingham
Most biological drugs cannot be given orally because of their poor oral bioavailability, necessitating delivery by injection instead. This is because features of the gastrointestinal tract that prevent infection, such as a thick mucus layer and tight epithelial junctions, also block large therapeutic molecules. Researchers have investigated various techniques to overcome these barriers, such as chemical permeation enhancers, ultrasound, and microneedles. Studies have also shown that mechanical stimulation via na...